TABLE 3.
Course of kidney function, blood pressure and metabolic parameters before and 12 mo after donation, n = 2049
| Parameter | Before donation mean (SD) |
12 mo after donation mean (SD) |
Mean Difference (95% CI) |
Cohen’s d | P value |
|---|---|---|---|---|---|
| Kidney function | |||||
| Creatinine (µmol/l) | 67.9 (±13.5) | 100.2 (±19.3) | 32.47 (31.86-33.08) | 2.36 | <0.0001 |
| eGFR, CKD-EPI (ml/min/1.73m2) | 95.3 (±14.2) | 62.9 (±13.7) | –31.74 (–32.24 to –31.24) | 2.84 | <0.0001 |
| UPCR (mg/mmol)a | 9.1 (±5.6) | 11.8 (±7.8) | 2.66 (2.22-3.12) | 0.13 | <0.0001 |
| UACR (mg/mmol)a | 1.1 (±2.7) | 1.2 (±3.0) | 0.13 (–0.04 to 0.31) | 0.04 | 0.13 |
| Blood pressure | |||||
| Systolic (mmHg) | 126.7 (±13.5) | 127.8 (±14.7) | 0.76 (0.07-1.46) | 0.05 | 0.03 |
| Diastolic (mmHg) | 77.4 (±8.7) | 80.5 (±9.1) | 2.76 (2.30-3.22) | 0.27 | <0.0001 |
| Metabolic variables | |||||
| HbA1c (%) | 5.4 (±0.4) | 5.4 (±0.3) | 0.05 (0.03-0.07) | 0.24 | <0.0001 |
| Body weight (kg) | 71.9 (±12.9) | 72.3 (±13.4) | 0.51 (0.31-0.70) | 0.05 | <0.0001 |
| BMI (kg/m2) | 25.5 (±3.8) | 25.7 (±4.1) | 0.26 (0.19-0.34) | 0.16 | <0.0001 |
aSamples with a urine creatinine value <3 mmol/l (n = 657) were excluded from the analysis of the UPCR and UACR as well as donors with no available urine sample (n = 471).
For all scores, the mean value (SD) is indicated. The differences between before donation and 12 mo after donation were analyzed by a paired t-test. As a measure of effect, the mean differences (95% CI) and corresponding Cohen’s d were calculated.
BMI, body mass index; CI, confidence interval; HbA1c, hemoglobin A1c; SD, standard deviation; UPCR, urine protein-to-creatinine ratio; UACR, urine albumin-to-creatinine ratio.