TABLE 2.
Unadjusted and adjusted HR (95% CI) for associations with BA and risk of HCC, both overall and stratified by diabetes, obesity, and HCV
| Total bile acids (µmol/L) | |||
| Overalla | Tertile 1 (0.025–6.38) | 1.00 (Reference) | 1.00 (Reference) |
| Tertile 2 (6.44–32.20) | 1.94 (0.94–4.02) | 1.78 (0.83–3.81) | |
| Tertile 3 (32.440–237.794) | 3.59 (1.84–7.00) | 3.69 (1.85–7.37) | |
| Diabetesb | Tertile 1 (0.03–6.38) | 1.00 (Reference) | 1.00 (Reference) |
| Tertile 2 (6.44–32.20) | 1.46 (0.61–3.50) | 1.29 (0.51–3.29) | |
| Tertile 3 (32.44–237.79) | 3.49 (1.62–7.49) | 3.00 (1.35–6.70) | |
| No diabetesb | Tertile 1 (0.03–6.38) | 1.00 (Reference) | 1.00 (Reference) |
| Tertile 2 (6.44–32.20) | 4.57 (1.00–20.82) | 4.23 (0.94–19.09) | |
| Tertile 3 (32.44–237.79) | 6.32 (1.46–27.44) | 6.05 (1.41–25.92) | |
| Obesityc | Tertile 1 (0.03–6.38) | 1.00 (Reference) | 1.00 (Reference) |
| Tertile 2 (6.44–32.20) | 1.21 (0.46–3.17) | 1.20 (0.45–3.17) | |
| Tertile 3 (32.44–237.79) | 3.36 (1.49–7.59) | 3.85 (1.62–9.15) | |
| No obesityc | Tertile 1 (0.03–6.38) | 1.00 (Reference) | 1.00 (Reference) |
| Tertile 2 (6.44–32.20) | 3.29 (1.05–10.33) | 2.85 (0.86–9.43) | |
| Tertile 3 (32.44–237.79) | 3.24 (1.02–10.27) | 2.75 (0.86–8.83) | |
| HCVa | Tertile 1 (0.03–6.38) | 1.00 (Reference) | 1.00 (Reference) |
| Tertile 2 (6.44–32.20) | 2.46 (0.91–6.62) | 2.00 (0.68–5.88) | |
| Tertile 3 (32.44–237.79) | 7.45 (2.99–18.54) | 5.92 (2.27–15.44) | |
| No HCVa | Tertile 1 (0.03–6.38) | 1.00 (Reference) | 1.00 (Reference) |
| Tertile 2 (6.44–32.20) | 1.46 (0.50–4.26) | 1.57 (0.50–4.99) | |
| Tertile 3 (32.44–237.79) | 2.11 (0.79–5.66) | 2.61 (0.94–7.23) | |
| Malea | Tertile 1 (0.03–6.38) | 1.00 (Reference) | 1.00 (Reference) |
| Tertile 2 (6.44–32.20) | 1.67 (0.75–3.75) | 1.41 (0.60–3.35) | |
| Tertile 3 (32.44–237.79) | 3.69 (1.78–7.66) | 3.48 (1.59–7.59) | |
| Femalea | Tertile 1 (0.03–6.38) | 1.00 (Reference) | 1.00 (Reference) |
| Tertile 2 (6.44–32.20) | 4.73 (0.58–38.83) | 5.08 (0.56–46.21) | |
| Tertile 3 (32.44–237.79) | 6.51 (0.85–50.20) | 5.97 (0.77–46.11) | |
a
Adjusted for race/ethnicity, smoking, alcohol drinking, diabetes, obesity, and AFP.
b
Adjusted for race/ethnicity, smoking, alcohol drinking, obesity, and AFP.
c
Adjusted for race/ethnicity, smoking, alcohol drinking, diabetes, and AFP.
Abbreviation: AFP, alpha-fetoprotein.