Fig. 5. Impact of HCN channel blocker on luminance adaptation in peripheral cones.

A Exemplar responses of a peripheral M/L cone to 10 ms light flashes at four different background light levels in the presence of HCN channel blocker ZD7288. Response amplitude has been converted into gain (mV/R^*). B Mean ± sem relative times to peak across backgrounds of peripheral cones in the presence of ZD7288 compared to that of foveal and peripheral cones without ZD7288 (replotted from Fig. 1). In each cell, the time to peak at each background was normalized by the time to peak at 5000 R^*/s in that cell. C Mean ± sem relative FWHM across backgrounds of peripheral cones in the presence of ZD7288 compared to that of foveal and peripheral cones without ZD7288 (replotted from Fig. 1). In each cell, the FWHM at each background was normalized by the FWHM at 5000 R^*/s in that cell. D The ratio of peak response amplitude and response integral of peripheral cones in the presence of ZD7288 (n = 1) compared to that of foveal and peripheral cones without ZD7288 (replotted from Fig. 2). Points with error bars represent mean ± sem response gains across a range of background luminance starting from 1000 R^*/s. Source data are provided as a Source Data file. We performed multi-way ANOVA with a multi-way comparison with three conditions. The significance threshold was placed at α = 0.05 (n.s., p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001).