Table 1.
miRNA expression in decompensated cirrhosis states and HC/cCLD.
| miRNA | N | Decompensated (n = 134) | N | cCLD/HC (n = 40) | p value | AUC |
|---|---|---|---|---|---|---|
| (A) | ||||||
| miR-103a | 134 | 298.72 (2.36) | 40 | 298.39 (2.07) | 0.43 | |
| miR-122 | 134 | 278.29 (12.02) | 40 | 272.35 (15.73) | 0.01* | 0.62 (0.51–0.73) |
| miR-150 | 134 | 280.95 (7.97) | 40 | 280.56 (9.15) | 0.79 | |
| miR-16-2 | 134 | 269.62 (9.15) | 39 | 269.15 (9.51) | 0.78 | |
| miR-17 | 113 | 243.87 (11.45) | 36 | 246.23 (13.34) | 0.30 | |
| miR-191 | 131 | 295.54 (1.10) | 39 | 295.37 (1.14) | 0.40 | |
| miR-200b | 19 | 236.38 (23.35) | 5 | 224.04 (25.23) | 0.31 | |
| miR-20a | 101 | 247.91 (6.86) | 35 | 249.25 (4.83) | 0.29 | |
| miR-223 | 134 | 310.35 (1.78) | 40 | 311.09 (1.58) | 0.02* | 0.63 (0.53–0.73) |
| miR-23a | 134 | 302.94 (1.55) | 40 | 302.90 (1.86) | 0.90 | |
| miR-24 | 134 | 302.60 (1.80) | 40 | 301.89 (1.90) | 0.03* | 0.62 (0.52–0.73) |
| miR-25 | 134 | 299.73 (6.30) | 40 | 297.51 (6.85) | 0.06 | |
| miR-26a | 134 | 296.91 (1.68) | 40 | 297.28 (1.76) | 0.22 | |
| miR-27a | 134 | 294.65 (2.08) | 40 | 295.69 (1.81) | 0.005* | 0.67 (0.58–0.76) |
| miR-29b | 134 | 261.77 (8.68) | 40 | 266.01 (6.86) | 0.005* | 0.65 (0.56–0.74) |
| miR-30a | 134 | 272.43 (8.27) | 40 | 268.23 (11.14) | 0.01* | 0.63 (0.52–0.74) |
| miR-330 | 45 | 226.72 (12.69) | 19 | 216.51 (14.51) | 0.006* | 0.72 (0.58–0.87) |
| miR-451a | 134 | 321.18 (6.02) | 40 | 321.16 (6.02) | 0.99 | |
| miR-503 | 102 | 251.84 (7.58) | 35 | 249.04 (7.09) | 0.06 | |
| miR-663 | 9 | 231.85 (19.60) | 3 | 192.46 (35.28) | 0.03* | 0.85 (0.62–1.00) |
| miRNA | Decompensated (n = 134) | Compensated (n = 40) | p value | |||
|---|---|---|---|---|---|---|
| (B) | ||||||
| miR-149 | 2 (1.49%) | 0 (0.00%) | > 0.9999 | |||
| miR-17 | 113 (84.33%) | 36 (90%) | 0.45 | |||
| miR-200b | 19 (14.18%) | 5 (12.50%) | > 0.9999 | |||
| miR-20a | 101 (75.4%) | 35 (87.50%) | 0.13 | |||
| miR-330 | 45 (33.58%) | 19 (47.5%) | 0.14 | |||
| miR-503 | 102 (76.12%) | 35 (87.50%) | 0.19 | |||
| miR-663 | 9 (6.72%) | 3 (7.50%) | > 0.9999 | |||
| miRNA | β value | OR | p value | |||
|---|---|---|---|---|---|---|
| (C) | ||||||
| miR-24 | 0.6491 | 1.91 (1.45–2.62) | < 0.0001* | |||
| miR-27a | − 0.6201 | 0.54 (0.41–0.69) | < 0.0001* | |||
(A) Results of t tests between patients with decompensated CLD states and HC/cCLD. Results given as mean (SD). If p < 0.05, AUC was calculated. (B) For miRNA detected in < 85% of samples, reanalysis was performed after converting results to either detected (1) or undetected (0) using Fisher’s exact test. Results given as number (%). (C) miRNA model utilized to distinguish decompensated CLD (n = 174, AUC 0.77 (95% CI 0.69-0.85, p < 0.0001*); pseudo r2 = 0.1849, HL stat 8.95 (p = 0.35). Statistical significance set after correction for false discovery with the Benjamini-Hochberg procedure (p < 0.0344) and designated by *.