Table 5.
Important metabolites selected on the basis of multiple hypothesis comparisons with Bonferroni correction.
| Metabolite | Adj. p value (among 3 groups) | SAP vs. Non-CVD | STEMI vs. Non-CVD | STEMI vs. SAP | |||
|---|---|---|---|---|---|---|---|
| Direction (for SAP) | Adj. p value | Direction (for STEMI) | Adj. p value | Direction (for STEMI) | Adj. p value | ||
| N-methylmalonamic acid (NMMA) | < 0.0001 | Increased | < 0.05 | – | – | Decreased | < 0.001 |
| Valine | < 0.01 | Increased | < 0.01 | – | – | Decreased | < 0.05 |
| Proline | – | – | – | – | – | Increased | < 0.05 |
| Phenylalanine | < 0.00001 | Increased | < 0.0001 | Increased | < 0.05 | – | – |
| Methionine | < 0.001 | – | – | – | – | Decreased | < 0.001 |
| Leucine | < 0.0001 | Increased | < 0.01 | – | – | Decreased | < 0.05 |
| Isoleucine | < 0.05 | Increased | < 0.05 | – | – | – | – |
| Glycine | < 0.01 | Decreased | < 0.05 | Decreased | < 0.05 | Decreased | < 0.05 |
| Asparagine | < 0.01 | – | – | – | – | Increased | < 0.01 |
| Aspartic acid | < 0.0001 | – | – | Decreased | < 0.001 | Decreased | < 0.001 |
| Glutamine | < 0.0001 | Increased | < 0.01 | Increased | < 0.0001 | Increased | < 0.05 |
| Carnitine (C0) | < 0.01 | Increased | < 0.01 | Increased | < 0.05 | – | – |
| Isovalerylcarnitine (C5) | < 0.0001 | Increased | < 0.01 | Increased | < 0.0001 | Increased | < 0.001 |
| Tiglylcarnitine (C5-1) | – | – | – | Increased | < 0.01 | Increased | < 0.05 |
| Adipoylcarnitine (C6-DC) | < 0.01 | Increased | < 0.01 | – | – | – | – |
| Decenoylcarnitine (C10-1) | < 0.001 | Increased | < 0.05 | – | – | Decreased | < 0.0001 |
| Decadienoylcarnitine (C10-2) | < 0.0001 | Increased | < 0.001 | – | – | Decreased | < 0.0001 |
| Hydroxytetradecanoylcarnitine (C14-OH) | < 0.0001 | Increased | < 0.0001 | – | – | – | – |
| Palmitoylcarnitine (C16) | < 0.01 | – | – | Increased | < 0.0001 | Increased | < 0.01 |
| Hydroxyhexadecanoylсarnitine (C16-OH) | < 0.0001 | Increased | < 0.0001 | Increased | < 0.01 | Decreased | < 0.05 |
| Palmitoleyl carnitine (C16-1) | < 0.05 | Increased | < 0.05 | Increased | < 0.001 | Increased | < 0.001 |
| Oleoylcarnitine (C18-1) | – | – | Increased | < 0.05 | – | – | |
| Hydroxystearoylcarnitine (C18-OH) | < 0.0001 | Increased | < 0.05 | Increased | < 0.0001 | Increased | < 0.05 |
| Symmetric dimethylarginine (SDMA) | < 0.01 | Increased | < 0.01 | Increased | < 0.05 | – | – |
| Methionine sulfoxide | < 0.0001 | – | – | Increased | < 0.0001 | Increased | < 0.0001 |
| Dimethylglycine (DMG) | < 0.0001 | Increased | < 0.0001 | Increased | < 0.0001 | – | – |
| Cystathionine | < 0.001 | Increased | < 0.001 | – | – | Decreased | < 0.01 |
| Citrulline | < 0.01 | – | – | – | – | Decreased | < 0.01 |
| Choline | < 0.0001 | Increased | < 0.0001 | – | – | ||
| Vanillylmandelic acid | < 0.001 | – | Increased | < 0.01 | Increased | < 0.05 | |
| Biopterin | < 0.001 | – | Increased | < 0.01 | Increased | < 0.01 | |
| Acetylcholine | < 0.01 | Increased | < 0.01 | Increased | < 0.05 | – | |
| 3-Amino isobutyric acid | < 0.01 | Increased | < 0.05 | – | Decreased | < 0.01 | |
| Kynurenine | < 0.01 | Increased | < 0.01 | – | – | ||
| 3-Hydroxykynurenine | < 0.001 | – | – | Decreased | < 0.001 | ||
| Kynurenic acid | < 0.0001 | Increased | < 0.001 | – | – | ||
| Anthranilic acid | < 0.0001 | Increased | < 0.001 | Increased | < 0.0001 | Increased | < 0.01 |
| Xanthurenic acid | < 0.01 | – | – | Decreased | < 0.01 | ||
| Tryptophol | < 0.0001 | – | Increased | < 0.0001 | Increased | < 0.0001 | |
| Indole-3-propionic acid | < 0.01 | – | Decreased | < 0.01 | |||
| Serotonin | < 0.05 | – | Increased | < 0.001 | – | ||