Table 4.
Association of the Breast Arterial Calcification Score and Clinical Outcomes
| Mortality aHR (95% CI) | P Value | Composite Outcomea aHR (95% CI) | P Value | |
|---|---|---|---|---|
| Among all participants | (n = 642/18,092) | (n = 1,082/17,720) | ||
| BAC negative, n = 13,869 | Referent | -- | Referent | -- |
| Per 10-point BAC score increase | 1.08 (1.06-1.11) | <0.001 | 1.08 (1.06-1.10) | <0.001 |
| First quartile [score 1-25], n = 2,552 | 1.22 (1.06-1.41) | 0.006 | 1.26 (1.11-1.43) | <0.001 |
| Second quartile [score 26-50], n = 643 | 1.44 (1.13-1.85) | 0.004 | 1.74 (1.42-2.13) | <0.001 |
| Third quartile [score 51-75], n = 509 | 1.69 (1.33-2.14) | <0.001 | 1.83 (1.49-2.25) | <0.001 |
| Fourth quartile [score 76-100], n = 519 | 2.27 (1.81-2.85) | <0.001 | 2.30 (1.88-2.82) | <0.001 |
| Excluding those prescribed statins | (n = 400/14,145) | (n = 739/14,145) | ||
| BAC negative, n = 11,352 | Referent | -- | Referent | -- |
| Per 10-point BAC score increase | 1.01 (1.007-1.013) | <0.001 | 1.01 (1.008-1.013) | <0.001 |
| First quartile [score 1-25], n = 1,838 | 1.27 (1.07-1.51) | 0.007 | 1.25 (1.07-1.46) | 0.006 |
| Second quartile [score 26-50], n = 390 | 1.48 (1.07-2.06) | 0.018 | 1.72 (1.31-2.27) | <0.001 |
| Third quartile [score 51-75], n = 295 | 1.58 (1.13-2.19) | 0.007 | 1.69 (1.26-2.25) | <0.001 |
| Fourth quartile [score 76-100], n = 270 | 2.53 (1.81-3.53) | <0.001 | 2.61 (1.97-3.47) | <0.001 |
| Excluding those with baseline ASCVDb | (n = 565/17,428) | (n = 1,025/17,428) | ||
| BAC negative, n = 13,540 | Referent | -- | Referent | -- |
| Per 10-point BAC score increase | 1.01 (1.006-1.011) | <0.001 | 1.01 (1.007-1.011) | <0.001 |
| First quartile [score 1-25], n = 2,414 | 1.21 (1.05-1.40) | 0.007 | 1.15 (0.97-1.36) | 0.111 |
| Second quartile [score 26-50], n = 593 | 1.39 (1.09-1.78) | 0.008 | 1.34 (0.98-1.83) | 0.071 |
| Third quartile [score 51-75], n = 459 | 1.59 (1.26-2.01) | <0.001 | 1.62 (1.15-2.29) | 0.006 |
| Fourth quartile [score 76-100], n = 422 | 2.20 (1.75-2.75) | <0.001 | 2.14 (1.53-3.00) | <0.001 |
aHR = adjusted HR; other abbreviation as in Table 3.
a
Composite outcome: acute myocardial infarction, heart failure, stroke, and mortality.
b
An additional 758 participants with any baseline ASCVD were excluded for the mortality outcome and an additional 399 participants with specific baseline conditions not already accounted for were excluded for the composite outcome. All data from the multivariable-adjusted model (Model 3), which adjusted for age, race/ethnicity, systolic blood pressure, diastolic blood pressure, diabetes, total cholesterol, low-density lipoprotein cholesterol, history of CVD, history of chronic kidney disease, and smoking status.