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. 1986 Jul 15;237(2):593–596. doi: 10.1042/bj2370593

Regulation by oestrogen of carnitine palmitoyltransferase in hepatic mitochondria.

I Weinstein, G A Cook, M Heimberg
PMCID: PMC1147025  PMID: 3800903

Abstract

Treatment of female rats with ethynyloestradiol decreased both the activity of carnitine palmitoyltransferase and its Ki value for malonyl-CoA compared with pair-fed control rats. In starved rats, carnitine palmitoyltransferase activity and its Ki value for malonyl-CoA were both elevated as expected. Oestrogen treatment had no effect on carnitine palmitoyltransferase activity in the starved state, but the Ki value for malonyl-CoA was substantially decreased by oestrogen. Treatment with a more physiological concentration of ethynyloestradiol (15 micrograms/kg body wt. per day) also produced a decrease in the Ki value for malonyl-CoA. These data suggest that the oestrogen may produce its anti-ketogenic effect by increasing the affinity of carnitine palmitoyltransferase for its physiological inhibitor, malonyl-CoA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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