Table 4.

Comparison of long-term renal function indicators (x̅±sd)

Parameter		Early SGLT2-i group (n = 88)	Late SGLT2-i group (n = 90)	t	P
UACR (mg/g)	Before treatment	161.25±12.36	160.78±12.81	0.252	0.801
	After 1 year treatment	85.39±7.62*	91.74±8.93*	5.108	< 0.001
	After 3 years treatment	72.46±7.52*	82.41±8.12*	8.480	< 0.001
	After 5 years treatment	54.29±6.58*	71.53±7.51*	16.305	< 0.001
	After 7 years treatment	41.87±7.23*	60.25±7.16*	17.047	< 0.001
eGFR [ml/(min·1.73 m2)]	Before treatment	73.25±8.38	73.69±8.02	0.359	0.720
	After 1 year treatment	85.36±10.25*	79.11±9.45*	4.230	< 0.001
	After 3 years treatment	96.14±10.36*	88.52±9.47*	5.120	< 0.001
	After 5 years treatment	105.42±10.56*	94.59±9.13*	7.309	< 0.001
	After 7 years treatment	113.38±10.51*	101.19±9.43*	8.139	< 0.001
Scr (μmol/L)	Before treatment	121.46±10.37	121.59±11.65	0.078	0.938
	After 1 year treatment	109.12±10.14	118.75±10.19	6.323	< 0.001
	After 3 years treatment	98.52±10.58	109.73±10.42	7.115	< 0.001
	After 5 years treatment	84.53±9.54	97.16±9.13	9.017	< 0.001
	After 7 years treatment	75.49±8.79	89.43±8.42	10.809	< 0.001

^*P < 0.05 compared to pre-treatment within the same group;

UACR, urine albumin-to-creatinine ratio; eGFR, estimated glomerular filtration rate; Scr, serum creatinine; SGLT2-i, sodium-glucose cotransporter 2 inhibitor.