Table 2.

Frequency and classification of mutations detected in the BRCA1, BRCA2, TP53, and PMS2 genes among prostate cancer patients

Sr. no	Gene	NM. DNA	Protein	Nature	No. patients
1	BRCA1	NM_007294.4	p.Cys61Gly	Pathogenic	10
		c.181T>G
2		NM_007294.4	p.Ala819fs	Pathogenic	10
		c.2457delC
3		NM_007294.4	p.Leu1786Arg	Benign	13
		c.5357T>G
4		NM_007294.4	p.Leu371Pro	Benign	11
		c.1111T>C
5		NM_007294.4	p.Thr401Arg	Benign	15
		c.1201C>G
6	BRCA2	NM_000059.4	p.Val2092fs	Pathogenic	10
		c.6275_6276del
7		NM_007294.4	p.Met1783Leu	Benign	17
		c.5347A>T
8		NM_007294.4	p.Asp1733Gly	Benign	21
		c.5198A>G
9		NM_007294.4	p.Thr1720Ala	Benign	34
		c.5158A>G
10		NM_007294.4	p.Gly1706Ala	Benign	12
		c.5117G>C
11	TP53	NM_000546.6	p.Glu339Ter	Pathogenic	10
		c.1014_1015insT
12		NM_000546.6	p.Arg306Ter	Pathogenic	10
		c.916C>T
13		NM_000546.6	p.Ser104Pro	Benign	8
		c.311T>C
14		NM_000546.6	p.Arg377Cys	Benign	9
		c.1129C>T
15	PMS2	NM_000535.7	p.Thr511Met	Benign	5
		c.1532C>T
16		NM_000535.7	p.Thr511Ala	Benign	11
		c.1531A>G
17		NM_000535.7	p.Lys484Lys	Benign	12
		c.1452G>A
18		NM_000535.7	p.Asn668Ser	Benign	11
		c.2002A>G
19		NM_000535.7	p.Lys728Lys	Benign	3
		c.2184G>A
20		NM_000535.7	p.Glu748Glu	Benign	11
		c.2244T>C
21		NM_000535.7	p.Ile841Va	Benign	1
		c.2522A>G
22		NM_000535.7	p.Leu855Leu	Benign	5
		c.2565G>A
23		NM_000535.7	p.Ser878Ser	Benign	7
		c.2634T>C
24		NM_000535.7	p.Pro908Pro	Benign	4
		c.2724C>T
25		NM_000535.7	p.Ala916Ala	Benign	13
		c.2748C>T
26		NM_000535.7	p.Tyr969Tyr	Benign	21
		c.2907T>C
27		NM_000535.7	p.Gln1001Gln	Benign	12
		c.3003G>A
28		NM_000535.7	p.Ser1048Ser	Benign	23
		c.3144T>C
29		NM_000535.7	p.Asp1072Asp	Benign	2
		c.3216C>T
30		NM_000535.7	p.Leu1092Leu	Benign	1
		c.3276G>A
31		NM_000535.7	p.Val1140Val	Benign	6
		c.3420T>C
32		NM_000535.7	p.Arg1193Arg	Benign	11
		c.3579A>G
33		NM_000535.7	p.Pro1240Pro	Benign	14
		c.3720C>T
34		NM_000535.7	p.Glu1267Glu	Benign	16
		c.3801G>A
35		NM_000535.7	p.Ile1300Ile	Benign	12
		c.3900A>G