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. 2024 Sep 15;16(9):4466–4478. doi: 10.62347/RRZF5229

Figure 3.

Figure 3

CB2 antagonist AM630 blocked esketamine-induced inhibition of pro-inflammatory cytokine release, nitrite accumulation and downregulation of iNOS and NF-κB (p65) expression. ELISA was used to measure cytokine release, and western blot analysis was performed to evaluate iNOS and NF-κB (p65) expression. A. The TNF-α concentration (n = 10). B. The IL-1β concentration (n = 10). C. The IL-6 concentration (n = 10). D. iNOS expression (n = 4). E. Nitrite concentration (n = 8). F. NF-κB (p65) expression (n = 4). *: P < 0.05; NS: no significance.