Table 2.

Co-primary outcomes, secondary outcomes and process measures

Outcome	Data extracted successfully
Co-primary outcomes
Antibiotic defined daily dose per admission	✓
30-day mortality	✓
Secondary outcomes
Length of hospital stay	✓
Days of therapy	✓
Days of IV therapy	✓
Diagnostics	✓
Number antibiotics prescribed	✓
Number antibiotic courses	✓
Repeat courses for same indication	✘
Number courses for same indication	✘
Switch of frequency	✘
Switch of dose	✘
IV to oral switch	✓
Oral to IV switch	✓
Switch to alternative antibiotic	✓
Switch to broad spectrum	✓
Discontinuation of therapy	✓
Courses concordant with local guidelines for antibiotic choice	✘
Courses concordant with local guidelines for antibiotic duration	✘
Resistance rates	✘
Susceptibility	✘
Acquisition of multi-drug resistant organism	✘
Healthcare-associated infection	✘
Episodes of Clostriodes difficile	✘
Episodes of methicillin-resistant Staphylococcus aureus	✘
Episodes of gram-negative Bacilli	✘
Process measures
Clinical decision support – workaround	✘
Clinical decision support – alert frequency	✘
Clinical decision support – alert override	✘
Clinical decision support – use of CDS order set	✓
Time to administration	✓
Time to active therapy (first dose)	✓
Time spent prescribing	✘
Documentation of indication	✘
Documentation of duration	✓
Documentation of stop	✓
Documentation of review	✓
Documentation of decision-making	✓
Switch from Reserve to Watch group antibiotic	✘
Switch from Watch to Reserve group antibiotic	✘
Adherence to clinical guidelines	✘
Adherence to documented sensitivity	✘
Appropriate dose for indication	✘

IV Intravenous