Table 3.
Results of mediation effects analysis in the total population
| variables | Model 1a | Model 2b | Model 3c | |||
|---|---|---|---|---|---|---|
| Percentage of mediation effect | P value | Percentage of mediation effect | P value | Percentage of mediation effect | P value | |
| All-cause death | ||||||
| TG |
9.1 (3.6,21.1) |
0.0076* |
6.2 (1.9,18.4) |
0.0375* |
6.6 (2.2,18.0) |
0.0258* |
| TC |
3.4 (1.1,10.3) |
0.0398* |
1.8 (0.3,10.1) |
0.1443 | - | - |
| HDL-C | - | - | - | - | - | - |
| LDL-C |
2.8 (0.6,12.9) |
0.1030 |
1.1 (0.1,17.4) |
0.2486 | - | - |
| Apo-AI | - | - |
2.7 (0.2,28.7) |
0.2282 |
2.3 (0.2,18.9) |
0.1881 |
| Apo-B |
1.5 (0.0,45.1) |
0.3077 | - | - |
1.1 (0.0,31.8) |
0.2979 |
| CV death | ||||||
| TG |
9.1 (3.4,22.1) |
0.0123* |
6.7 (2.1,19.6) |
0.0364* |
7.0 (2.3,19.6) |
0.0301* |
| TC |
2.9 (0.7,10.9) |
0.0737 |
1.6 (0.2,10.7) |
0.1650 | - | - |
| HDL-C | - | - | - | - | - | - |
| LDL-C |
1.6 (0.1,22.3) |
0.2396 | - | - | - | - |
| Apo-AI | - | - |
3.8 (0.5,24.2) |
0.1693 |
3.5 (0.6,19.0) |
0.1395 |
| Apo-B | - | - | - | - | - | - |
| MACCEs | ||||||
| TG |
14 (6.1,29.0) |
0.0026* |
10.2 (3.0,29.5) |
0.0288* |
10.2 (3.3,27.4) |
0.0185* |
| TC |
6.3 (2.4,15.4) |
0.0115* |
2.4 (0.2,25.5) |
0.2245 |
1.9 (0.1,33.8) |
0.2724 |
| HDL-C | - | - | - | - | - | - |
| LDL-C |
8.4 (3.7,18.2) |
0.0031* |
4.4 (1.0,17.3) |
0.0810 |
3.8 (0.7,18.8) |
0.1223 |
| Apo-AI | - | - | - | - | - | - |
| Apo-B |
10.6 (4.7,22.0) |
0.0018* |
5.7 (1.6,18.6) |
0.0447* |
6.1 (1.7,19.6) |
0.0470* |
*p<0.05
aModel 1 unadjusted
bModel 2 adjusted for age, sex
cModel 3 adjusted for age, sex, LVEF, hypertension, DM , eGFR, CRP