. 2024 Oct 7;25(5):839–854. doi: 10.1007/s11154-024-09897-7

Table 3.

Studies reporting overall and cardiovascular standardised mortality ratios (SMR) by sex

Study	Etiology of hypo-pituitarism	SMR all-cause	SMR all cause men	SMR all cause women	SMR cardio-vascular	SMR cardio-vascular men	SMR cardio-vascular women
Rosen [4] (1990)	Mixed	1.81	1.47	2.28	1.95	1.7	2.7
Bates [94] (1996)	Mixed	1.73 (1.28–2.28)*	1.50 (1.02–2.13)*	2.29 (1.37–3.58)*	1.35 (0.84–2.07)	1.32 (0.74–2.17)	1.46 (0.5–3.2)
Bulow [95] (1997)	Mixed	2.17 (1.88–2.51)*	1.91 (1.59–2.28)*	2.93 (2.28–3.75)*	1.75 (1.40–2.19)*	1.54 (1.16–2.03)*	2.39 (1.60–3.52)*
Bates [96] (1999)	NFPA	1.2 (0.95–1.55)	1.2	1.3	0.7 (0.5–1.1)	0.9 (0.5–1.4)	0.5 (0.2-1.0)
Nilsson [97] (2000)	NFPA	2.0 (1.9–2.2)*	1.88 (1.72–2.05)*	2.28 (2.04–2.54)*	1.56 (1.4–1.73)*	1.44 (1.26–1.65)*	1.79 (1.50–2.13)*
Tomlinson [5] (2001)	Mixed	1.87 (1.62–2.16)*	1.57 (1.19–2.06)*	2.29 (1.75-3.0)*	1.82 (1.30–2.54)*	1.7	2.34
Svensson [98] (2004)	Mixed	3.8 (3.43–4.19)*	3.36 (2.93–3.38)*	4.54 (3.89–5.26)*	1.4 (1.10–1.75)*	1.20 (0.88–1.60)	1.87 (1.27–2.65)*
Lindholm [99] (2006)	NFPA	1.18 (0.87–1.60)	0.83 (0.55–1.26)	1.97 (1.2–3.21)*	NR	NR	NR
Stochholm [100] (2007)	Mixed	NR	1.90 (1.7–2.2)*	3.4 (2.9-4.0)*	1.9 (1.5–2.3)*	NR	NR
Nielsen [101] (2007)	NFPA	1.21 (0.93–1.59)	0.98 (0.70–1.37)	2.11 (1.35–3.31)*	1.07 (0.59–1.84)	1.07 (0.59–1.93)	1.09 (0.27–4.36)
Olsson [102] (2015)	NFPA	1.06 (0.94–1.19)	0.94 (0.81–1.08)	1.38 (1.12–1.66)*	1.21 (1.06–1.38)*	0.98 (0.78–1.12)	1.66 (1.23–2.18)*
Ntali [103] (2016)	NFPA	3.8 (2.0-4.7)*	NR	NR	NR	NR	NR
van Bunderen [104] (2011)	Mixed	1.29 (1.05–1.59)*	1.01 (0.76–1.35)	1.87 (1.38–2.54)*	1.29 (0.88–1.89)	0.75 (0.42–1.36)	2.67 (1.61–4.44)*
Gaillard [105] (2012)	Mixed	1.13 (1.04–1.24)*	0.94 (0.84–1.06)	1.56 (1.36–1.78)*	0.83 (0.63–1.08)	N.R.	N.R.
Burman [106] (2013)	Mixed	1.42 (1.18–1.70)*	1.33 (1.05–1.66)*	1.63 (1.18 − 2.18)*	1.82 (0.91–3.26)	NR	NR

Study

Etiology of hypo-pituitarism

SMR all-cause

SMR all cause men

SMR all cause women

SMR cardio-vascular

SMR cardio-vascular men

SMR cardio-vascular women

Rosen [4]

(1990)

Mixed

1.81

1.47

2.28

1.95

1.7

2.7

Bates [94]

(1996)

Mixed

1.73

(1.28–2.28)*

1.50

(1.02–2.13)*

2.29

(1.37–3.58)*

1.35

(0.84–2.07)

1.32

(0.74–2.17)

1.46

(0.5–3.2)

Bulow [95]

(1997)

Mixed

2.17

(1.88–2.51)*

1.91

(1.59–2.28)*

2.93

(2.28–3.75)*

1.75

(1.40–2.19)*

1.54

(1.16–2.03)*

2.39

(1.60–3.52)*

Bates [96]

(1999)

NFPA

1.2

(0.95–1.55)

1.2

1.3

0.7

(0.5–1.1)

0.9

(0.5–1.4)

0.5

(0.2-1.0)

Nilsson [97]

(2000)

NFPA

2.0

(1.9–2.2)*

1.88

(1.72–2.05)*

2.28

(2.04–2.54)*

1.56

(1.4–1.73)*

1.44

(1.26–1.65)*

1.79

(1.50–2.13)*

Tomlinson [5]

(2001)

Mixed

1.87

(1.62–2.16)*

1.57

(1.19–2.06)*

2.29

(1.75-3.0)*

1.82

(1.30–2.54)*

1.7

2.34

Svensson [98]

(2004)

Mixed

3.8

(3.43–4.19)*

3.36

(2.93–3.38)*

4.54

(3.89–5.26)*

1.4

(1.10–1.75)*

1.20

(0.88–1.60)

1.87

(1.27–2.65)*

Lindholm [99]

(2006)

NFPA

1.18

(0.87–1.60)

0.83

(0.55–1.26)

1.97

(1.2–3.21)*

Stochholm [100]

(2007)

Mixed

1.90

(1.7–2.2)*

3.4

(2.9-4.0)*

1.9

(1.5–2.3)*

Nielsen [101]

(2007)

NFPA

1.21

(0.93–1.59)

0.98

(0.70–1.37)

2.11

(1.35–3.31)*

1.07

(0.59–1.84)

1.07

(0.59–1.93)

1.09

(0.27–4.36)

Olsson [102]

(2015)

NFPA

1.06

(0.94–1.19)

0.94

(0.81–1.08)

1.38

(1.12–1.66)*

1.21

(1.06–1.38)*

0.98

(0.78–1.12)

1.66

(1.23–2.18)*

Ntali [103]

(2016)

NFPA

3.8

(2.0-4.7)*

van Bunderen [104]

(2011)

Mixed

1.29

(1.05–1.59)*

1.01

(0.76–1.35)

1.87

(1.38–2.54)*

1.29 (0.88–1.89)

0.75 (0.42–1.36)

2.67 (1.61–4.44)*

Gaillard [105]

(2012)

Mixed

1.13

(1.04–1.24)*

0.94

(0.84–1.06)

1.56

(1.36–1.78)*

0.83 (0.63–1.08)

N.R.

Burman [106]

(2013)

Mixed

1.42

(1.18–1.70)*

1.33

(1.05–1.66)*

1.63

(1.18 − 2.18)*

1.82 (0.91–3.26)

^{Results reported as a SMR with 95% confidence intervals. * Indicates statistically significant result. NR− not reported}