Table 1.

Proposed clinical and research priorities for addressing the neuropsychiatric features of Susac syndrome

Domain	Goals	Proposed strategies
Phenotyping	• Clarify the nature of neuropsychiatric features in Susac syndrome • Identify those at risk of developing neuropsychiatric symptoms in Susac syndrome	• Development of a proposed standardised battery evaluating cognitive and psychiatric symptoms at presentation and longitudinally • Development of a multisite, international registry • Development of a minimum dataset for application by registry participants
Pathophysiology	• Determine if neuropsychiatric symptoms in Susac syndrome are directly related to the disease process or secondary to the functional impacts of the illness and treatments	• Identify reliable biomarkers (peripheral blood, neuroimaging, CSF, and histopathology), and investigate the relationship between clinical phenotypes and these biomarkers
Treatment	• Develop an evidence-based therapeutic guideline for Susac syndrome, which takes into consideration cognitive and psychiatric outcomes • Understand the role of psychotropic medication in targeting neuropsychiatric symptoms in Susac syndrome	• Development of a multicentre, international patient registry which involves capture of a minimum data set on treatment and neuropsychiatric outcomes • Investigate the correlation between the nature/dose/duration of treatment and cognitive and psychiatric outcomes
Long-term outcomes	• Better understand the cognitive and psychiatric prognosis of Susac syndrome • Understand the predictors of long-term cognitive and psychiatric outcomes in Susac syndrome	• Inclusion of cognitive, psychiatric, and functional assessments longitudinally