Table 4.
Epidemiology of ACTH deficit and other pituitary hormones deficit in pituitary adenoma/neuroendocrine tumors
| Authors (Reference) | Num of patients |
Age at diagnosis mean (ranges) |
Gender M/F (%) |
Timing of pituitary function evaluation | Size | Frequency of pituitary hormones deficit | |||
|---|---|---|---|---|---|---|---|---|---|
| ACTH-deficit | TSH-deficit | FSH/LH-deficit | GH-deficit | ||||||
| Grayson et al. [60] | 89/279a | 54 yrs | M: 52% F: 48% | N.A. | 9.6% < 10 mm, 90.4% 10–40 mm | 14.8% | 14.8% | 6.8% | 2.3% |
| Grayson et al. [60] | 190/279b | N.A. | 14.7% < 10 mm, 85.3% 10–40 mm | 8.6% | 4.8% | 4.3% | 0% | ||
| Mukai et al. [61] | 63 | 58 yrs (47–70) | M: 66.7% F: 33.3% | After pituitary surgery | Median diameter 2.56 (2.06–3.16) cm | 55% | 30% | 41% | 59% |
| Mavromati et al. [62] | 137 | 59 yrs (28–86) | M:59.1% F: 40.9% | Before pituitary surgery | Median diameter 2.48 (1–5) cm | 30.8% | 41% | 62.4% | 29.9% |
| After pituitary surgery | 27.4% | 29.3% | 40.8% | 17% | |||||
| Hwang et al. [63] | 209 | 58 yrs (49–66) | M: 56.5% F: 43.5% | Before pituitary surgery |
Tumor volume 4.9 (2.9–10.1) cm3 Median diameter 2.6 (2–3.1) cm |
42.5% | 42.5% | 76.8% only males | 25.8% |
| After pituitary surgery | 9.7% | 24.3% | 15.4% only males | 19.4% | |||||
| Jahangiri et al. [59] | 305 | 57 (16–93) | M: 55.7% F: 44.3% | Before pituitary surgery | Median diameter 2.2 (3–7.1) cm | 13% | 26% |
20% males 16% females |
19% |
N.A. data not available, M male, F female, ACTH AdrenoCorticoTropic Hormone, TSH Thyroid-Stimulating Hormone, FSH Follicle-Stimulating Hormone, LH Luteinizing Hormone, Yrs years
aData on 89 patients were collected before evaluation from a multidisciplinary team care
bData on 190 patients were collected after evaluation from a multidisciplinary team care