Table 7.
Epidemiology of ACTH deficit and other pituitary hormones deficit in sellar and parasellar not secreting pituitary lesions
| Authors (Reference) | Etiology | Num of patients |
Age at diagnosis mean (ranges) |
Gender M/F (%) |
Frequency of pituitary hormones deficit | ||||
|---|---|---|---|---|---|---|---|---|---|
|
ACTH- deficit |
TSH- deficit |
FSH/LH- deficit |
GH- deficit |
AVP- deficit |
|||||
| Henry et al. [114] | Metastasis | 4 | 46.5 (19–73) | M: 75% F: 25% | 25% | 50% | 75% | N.A. | 25% |
| Javanbakht et al. [116] | Metastasis | 11 | 59.2 (43–76) | M: 54.5% F: 45.5% | 27.3% | 27.3% | 27.3% | 27.3% | 27.3% |
| Lithgow et al. [117] | Metastasis | 18 | 61.5 | M: 22.2% F: 77.8% | 67% | 46% | 85% | N.A. | N.A. |
| Mattogno et al. [118] | Metastasis | 2 | 32 | M: 100% F: 0% | 50% | N.A. | N.A. | N.A. | N.A. |
| Partenope et al. [129] | Germinoma | 55 | 11 (8–14) | M: 32.7% F: 67.3% | 54.5% | 49.1% | 49.1% | 54.5% | 52.7% |
| Chang et al. [131] | Germinoma | 49 | 13.6 (7.5–19) | M: 75.5% F: 24.5% | 42.8% | 30.6% | 8.1% | 36.7% | 55.1% |
| Xiang et al. [134] | Germinoma | 77 | 18 | M: 80.5% F: 19.5% | 57.3% | 56% | 56.6% | N.A. | 52.1% |
| Moszczyńska et al. [136] | Germinoma | 23 | 9.68 | M: 56.5% F: 43.5% | 65.2% | 69.6% | 47.8% | 47.8% | 69.6% |
| Brys et al. [141] | Histiocytosis | 3 | 45.3 (41–51) | M: 75% F: 25% | 0% | 25% | 75% | N.A. | 100% |
| Huo et al. [142] | Histiocytosis | 7 | 28 (9–47) | M: 42.8% F: 57.2% | 42,8% | 42,8% | 57,1% | 57,1% | 100% |
| Montefusco et al. [143] | Histiocytosis | 18 | 42 | M: 38.9% F: 61.1% | 5.5% | 16.7% | 27.8% | 27.8% | 5.5% |
N.A. data not available, M male, F female, ACTH AdrenoCorticoTropic Hormone, TSH Thyroid-Stimulating Hormone, FSH Follicle-Stimulating Hormone, LH Luteinizing Hormone, Yrs years, AVP Arginine VasoPressin, GH Growth Hormone