Table 2.
Mendelian randomization estimates for the association of estradiol level using 3-SNPs with risk of lung or colorectal cancer among women in HUNT.
| Cases | Estradiola | ||||
|---|---|---|---|---|---|
| HRb (95% CI) | p-value | Q-statistic | p of Q-statistic | ||
| Lung cancer | 468 | 0.78 (0.28–2.18) | 0.64 | 10 | 0.008 |
| Lung adenocarcinoma | 174 | 0.52 (0.09–2.87) | 0.45 | 3 | 0.27 |
| Lung non-adenocarcinoma | 294 | 1.00 (0.28–3.63) | 1.00 | 7 | 0.03 |
| Colorectal cancer | 984 | 0.53 (0.26–1.08) | 0.08 | 2 | 0.38 |
| Colon cancer | 733 | 0.38 (0.16–0.88) | 0.02 | 3 | 0.20 |
| Rectal cancer | 251 | 1.32 (0.32–5.34) | 0.70 | 2 | 0.43 |
CI confidence interval, HR hazard ratio, IVW inverse-variance weighted, MR Mendelian randomization, SD standard deviation.
aTwo-sample MR was performed using data on 3-SNPs (rs4764934, rs897797, rs16991615) from Schmitz22 for estradiol level and from HUNT for lung or colorectal cancer.
b Per one-SD increase in genetically predicted rank-transformed estradiol level, based on the IVW method.