Table 5.

Mendelian randomization estimates for the association of SHBG level with risk of lung or colorectal cancer among women in HUNT.

	Cases	SHBGa
		HRb (95% CI)	p-value	Q-statistic	p of Q-statistic
Lung cancer	468	1.44 (0.71–2.90)	0.31	184	0.31
Lung adenocarcinoma	174	1.04 (0.34–3.21)	0.95	177	0.44
Lung non-adenocarcinoma	294	1.73 (0.70–4.25)	0.23	190	0.20
Colorectal cancer	971	1.14 (0.70–1.84)	0.60	179	0.40
Colon cancer	723	1.26 (0.73–2.19)	0.41	175	0.49
Rectal cancer	248	0.87 (0.34–2.27)	0.78	181	0.37

CI confidence interval, HR hazard ratio, IVW inverse-variance weighted, MR Mendelian randomization, SD standard deviation, SHBG sex hormone binding globulin.

^aTwo-sample MR was performed using summary statistics from Ruth²³ for SHBG level and from HUNT for lung or colorectal cancer.

^bAdjusted for body mass index, per one-SD increase in genetically predicted SHBG level, based on the IVW method.