Table 3.
Metabolic features of SOFT syndrome
| Total | number of missing data among the whole group of 42 reported patients | |
|---|---|---|
| Metabolic involvement | 10/11 (91%) | 31 |
| Median (range) of BMI at investigation (kg/m2 or IOTF) | 23.05 (15–28.57) | 32 |
| Central distribution of fat | 8/11 (73%) | 31 |
| Clinical and/or biological sign of insulin resistance | 10/11 (91%) | 31 |
| Acanthosis nigricans | 7/11 (64%) | 31 |
| Median (range) fasting blood glucose (mmol/L) | 5.1 (4–15.7) | 33 |
| Median (range) fasting insulinemia (mUI/L) | 57.1 (12.96–241.2) | |
| Median (range) HOMA-IR | 18 (2.9–54.6) | 35 |
| Median (range) OGTT-120 min blood glucose (mmol/L)/ | 8.75 (6.8–25.3) | 34 |
| Median (range) OGTT-120 min insulinemia (mUI/L) | 449 (62–1818) | |
| Median (range) HbA1C | 5.6 (5–9.6) | 37 |
| Glucose tolerance abnormality and/or diabetes | ||
| - In all children | 7/42 (17%) | 0 |
| - In children aged over 10 years | 7/12 (58%) | 0 |
| Diabetes | ||
| - In all children | 5/42 (12%) | 0 |
| - In children aged over 10 years | 5/12 (42%) | 0 |
| Dyslipidemia | 8/10 (80%) | 32 |
| Hypertriglyceridemia | 4/6 (67%) | 36 |
| Hepatic steatosis | 8/8 (100%) | 34 |
| Hepatic transaminases (AST- ALT, times higher than N) | 2 (2–3) | 35 |
The median was used to summarize the continuous quantitative variables with extreme values (range) in parentheses. The frequencies were used to summarize the qualitative variables and were reported as "No. (%)"
Some qualitative variables were compared using Fisher's Exact test. Significance was determined based on p value < 0.05
Biological IR and dyslipidemia were defined respectively by: HOMA-IR score > 2.4 and lipid panel abnormalities (LDL-chol > 160 mg/dL and/or HDL-chol < 40 mg/dL and/or triglyceridemia > 175 mg/dL) [13]
BMI Body Mass Index, HOMA-IR homeostasis model assessment-estimated IR, IOTF International Obesity Task Force (IOTF), OGTT oral glucose tolerance test, SDS standard deviation score