Fig. 4. PEC in vivo monitoring of TET for practical application.
a Photographs of E. coli infected wounds on days of 1, 4, 7, 10 and 13 with different treatments of PBS, C-TET, TDM-CM, and TDM-HM; b mean wound areas on mice with different treatments, error bars correspond to the standard deviation of five independent measurements (n = 5); c body weight changes of mice in E. coli-infected model after different treatments, error bars correspond to the standard deviation of five independent measurements (n = 5); d I-T curves of medicine concentration monitoring in TDM-CM group; e photographs of agar plates of E. coli colony after PBS, C-TET, TDM-CM, and TDM-HM treatments; f survival rate of E. coli in the infected wound tissues using colony forming unit (CFU) method, error bars correspond to the standard deviation of five independent measurements (n = 5); g H and E staining images (n = 3) of liver, lung, and kidney tissue sections after PBS, TET, TDM-CM and TDM-HM treatments, the scale bar is 500 μm.
