Figure 2.

Investigation of COVID-19 repertoire from a structural perspective. (A) Antibody structural space in VCAb. The majority (53.5%) of antibody structures in VCAb is from human, among which 2721/3832 (71.0%) of these are co-complexed with antigens. (B) Two sequences from the sampled repertoire (Stewart et al. 2022) are inputted into VCAb to search for matches in the dataset of resolved antibody structures. We obtained a structural match (left, PDB 7tn0) showing the recognition of the RBD epitope distinct from ACE2 binding site. For the other sequence (right), the corresponding structure match (PDB 7bz5) shows this antibody directly blocking ACE2 binding. RBD, receptor binding domain.