Table I.
Patient demographics and tumour data.
| Variable | Total (n = 40) | Reconstruction methods | ||||
|---|---|---|---|---|---|---|
| Expandable prosthesis (n = 15) | Spacer (n = 9) | Modular prosthesis (n = 11) | Biological reconstruction (n = 5) | p-value | ||
| Patient data | ||||||
| Sex, n (%) | 0.357* | |||||
| Male | 19 (48) | 6 (40) | 5 (56) | 4 (36) | 4 (80) | |
| Female | 21 (52) | 9 (60) | 4 (44) | 7 (64) | 1 (20) | |
| Median age at operation, yrs (IQR) | 11 (10 to 13) | 11 (9 to 11) | 12 (10 to 12) | 14 (13 to 14) | 14 (10 to 14) | 0.001† |
| Median height at operation, cm (IQR) | 147.3 (136.5 to 163.9) |
141.8 (135.0 to 146.2) |
140.0 (126.8 to 146.5) |
163.2 (153.7 to 167.5) |
170.0 (149.0.0 to 170.0) | 0.005† |
| Tumour data | ||||||
| Site, n (%) | 0.210* | |||||
| Distal femur | 25 (63) | 11 (73) | 3 (33) | 8 (73) | 3 (60) | |
| Proximal tibia | 15 (37) | 4 (27) | 6 (67) | 3 (27) | 2 (40) | |
| Median maximum tumour diameter, cm (IQR) | 8.7 (7.1 to 11.0) | 7.6 (6.4 to 9.3) | 9.7 (8.1 to 10.8) | 10.4 (8.6 to 13.5) | 6.4 (5.2 to 8.6) | 0.092† |
| TNM, n (%) | 0.276* | |||||
| Stage IIA | 15 (38) | 8 (53) | 2 (22) | 2 (18) | 3 (60) | |
| Stage IIB | 24 (60) | 7 (47) | 7 (78) | 8 (73) | 2 (40) | |
| Stage IVB | 1 (2) | 0 | 0 | 1 (9) | 0 | |
| Oncological results | ||||||
| Median follow-up, mths (IQR) | 135.2 (95.2 to 166.1) | 108.0 (96.6 to 141.8) | 183.5 (161.3 to 203.2) |
113.6 ( 85.2 to 121.8) | 121.6 (105.0 to 180.6) | 0.022† |
| Local recurrence, n (%) | ||||||
| Yes | 0 | 0 | 0 | 0 | 0 | |
| No | 40 (100) | 15 (100) | 9 (100) | 11 (100) | 5 (100) | |
| Distant metastases, n (%) | 0.124* | |||||
| Yes | 8 (20) | 2 (13) | 0 | 4 (36) | 2 (40) | |
| No | 32 (80) | 13 (87) | 9 (100) | 7 (64) | 3 (60) | |
| Outcome at the final follow-up, n (%) | 0.124* | |||||
| CDF | 32 (80) | 13 (87) | 9 (100) | 7 (64) | 3 (60) | |
| NED | 8 (20) | 2 (13) | 0 | 4 (36) | 2 (40) | |
*
Chi-squared test.
†
Kruskal-Wallis test.
CDF, continuous disease-free; NED, no evidence of disease.