Table 2.

Diversification of A-to-I editing in S. pyogenes

	tRNAArgACG-only species		S. pyogenes
	(UACG)		(UACG and UAAG)
Codon position of inosine	Amino acid	Codon	Amino acid	Codon
C1	Thr-to-Ala	ACG-to-ICG	Thr-to-Ala	ACG-to-ICG
			Lys-to-Glu	AAG-to-IAG
C2	Tyr-to-Cys	UAC-to-UIC	Tyr-to-Cys	UAC-to-UIC
			stop codon	UAA-to-UIA
C3	Leu	YUA-to-YUI	Leu	YUA-to-YUI
	[ Ile-to-Met ]	[ AUA-to-AUI ]	[ Ile-to-Met ]	[ AUA-to-AUI ]
	[ Val ]	[ GUA-to-GUI ]	[ Val ]	[ GUA-to-GUI ]

The possible outcomes of A-to-I editing in tRNA^Arg_ACG-only species, such as E. coli or K. pneumoniae (left), and S. pyogenes (right) are based on the minimum core consensus sequences of each species (in brackets, as reported in (21,23) and here) and listed according to the presence of inosine at the respective codon position (C1 to C3). Effects are shown at the amino acid and codon level. The editing events in square brackets contain the core consensus sequence but have no pyrimidine at position -2 relative to inosine and are therefore unfavoured.