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. 2024 Sep 20;67(19):17070–17086. doi: 10.1021/acs.jmedchem.4c00212

Scheme 2. General Synthetic Procedure Followed for the Synthesis of 4–18.

Scheme 2

Reagents and conditions: (a) triphosgene, Et3N, DCM, 0 °C to room temperature, 3 h, used without purification in the next reaction step; (b) 3-(pyrrolidin-1-ylsulfonyl)aniline, DMF, room temperature, overnight, 8–95% yield.