Table 7. In Vivo PK Data for Compounds 10 and 28.
| in vivo PKa | 10 | 28 |
|---|---|---|
| T1/2 [h] | 0.05 ± 0.1 | 1.55 ± 0.5 |
| C0 [ng/mL] | 912.6 ± 400.2 | 433.1 ± 256.6 |
| AUC0–t [ng/mL·h] | 246.4 ± 63.3 | 717.4 ± 135.9 |
| MRT [h] | 0.6 ± 0.2 | 2.24 ± 0.7 |
| Vz_obs [L/kg] | 2.5 ± 0.8 | 2.9 ± 1.2 |
| Cl_obs [mL/min/kg] | 53.0 ± 8.5 | 20.9 ± 2.0 |
| liver ng/g | ND | 202.6 ± 45.8 |
a
Assays were performed in replicate as independent experiments (n = 2 mice); values are shown as mean ± SD. AUC0–t = area under the concentration–time curve from time zero to time t; MRT = mean residence time; Vz_obs = observed volume of distribution; Cl_obs = observed clearance (based on observed last time point with measurable concentration); ND = not detected.