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. 2024 Oct 14;23:275. doi: 10.1186/s12934-024-02549-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Deletion of hupA and/or hupS changes expression DNA topology maintenance and global regulators genes (A) Heatmap showing normalized expression (CPM) of genes connected with DNA topology and spore development in wild type, ΔhupA, ΔhupS and ΔhupAΔhupS s trains during mid-log and early stationary phase. (B) Heatmap showing normalized expression (CPM) of SigB regulon genes in wild type, ΔhupA, ΔhupS and ΔhupAΔhupS s trains during mid-log and early stationary phase. (C) Selected genes from differentiation and stress response networks that are upregulated (blue) or downregulated (red) in the ΔhupAΔhupS strain during early stationary phase. A,B Genes marked with diamond were found to be significantly changed in comparison to the wild type strain (FDR ≤ 0.05)