Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Sep 10;7:32. doi: 10.20517/cdr.2024.55

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024.

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

A schematic presentation of different branches/subtypes of CAFs in lung cancer CAFs. Single-cell RNAseq analysis revealed heterogeneity of CAFs in NSCLC. Kim et al. identified different branches of CAFs^[150], including immunosuppressive, ApCAFs, myCAFs, and proliferative CAFs. Hu et al. introduced three subtypes with various HGF and FGF expression levels^[151]. Five unique CAFs were found in Lambrechts’s investigation; one was categorized as non-malignant fibroblasts^[152]. CAFs: Cancer-associated fibroblasts; NSCLC: non-small cell lung cancer; ApCAFs: antigen-presenting CAFs; myCAFs: myofibroblast-like CAFs; HGF: hepatocyte growth factor; FGF: fibroblast growth factor.