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. Author manuscript; available in PMC: 2024 Oct 14.
Published in final edited form as: Compr Physiol. 2023 Mar 30;13(2):4409–4491. doi: 10.1002/cphy.c190043

Figure 9: The role for the renal aldosterone endothelin feedback system (RAEFS) on mineralocorticoid-stimulated Na+ retention.

Figure 9:

Normal mice are shown in black lines and squares. Mice not expressing ET-1 in the collecting duct (CD ET-1 KO) are shown in dashed lines and open circles. Normal mice exhibit transient Na+ retention before escaping from progressive positive Na+ balance. CD ET-1 KO fail to undergo aldosterone escape, with persistent positive daily Na+ balance. Daily Na+ balance over days 1–19. Solid lines are controls, and dotted lines are CD ET-1 KO. Control, n = 9; CD ET-1 KO, n = 6. Data is shown as means + SE. In B, *P < 0.05 within control, day 1 vs. days 2, 3, 6, and 7, Tukey's test; †P < 0.05 within control, day 11 vs. days 9–12 and 14–19, Tukey's test; ‡P < 0.05, significant effect of genotype, repeated-measures ANOVA. Adapted from Lynch et al (506).