Table 2 –

Comparison of affinities of mineralocorticoid receptor (MR), glucocorticoid receptor (GR), and estrogen receptor ß (ERß) for cognate ligands and other corticosteroids

Receptor	Ligand	Affinity
Mineralocorticoid Receptor (MR)	Aldosterone	0.5–3 nM
	Deoxycorticosterone (DOC)	Similar to aldosterone in vitro; 2% of aldosterone in vivo
	Cortisol	~0.5 nM
	Dexamethasone	~0.7 nM
	Progesterone	High, but lower than corticosteroids
	Estradiol	Very poor
Glucocorticoid Receptor (GR)	Aldosterone	~ 14 nM
	Cortisol	~ 12 nM
	Dexamethasone	~ 4nM
Estrogen Receptor ß (Erß)	Estradiol	1nM for ERß1; 8nM for ERß2