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. 2024 Oct 14;9(6):e1202. doi: 10.1097/PR9.0000000000001202

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Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 1. — Theoretical representation of the holistic MCID. Five core domains of pain intensity, physical function, health-related quality of life, sleep quality, and emotional function were evaluated. (A) In this example, a hypothetical “Patient A” had baseline impairment for pain intensity, health-related quality of life, and physical function. Patient A obtained 2 MCIDs for each of pain intensity and health-related quality of life domains, and 1 MCID for physical function domain, which corresponds to a cumulative responder score of 5 MCIDs. Adjusting the cumulative responder score of 5 MCIDs by 3 impaired domains at baseline results in a holistic MCID score of 1.7. (B) A hypothetical “Patient B” had baseline impairment in the 5 domains and obtained 2 MCIDs for each of pain intensity and health-related quality of life domains, and 1 MCID for each of sleep quality, physical, and emotional function domains, corresponding to a cumulative responder score of 7 MCIDs. Adjusting the cumulative responder score of 7 MCIDs by 5 impaired domains at baseline results in a holistic MCID score of 1.4.