TABLE 2.
Production of total human IgG in human-mouse chimeras
| Exptl groupa | n | Mean IgG ± SD (μg/ml) produced with PBL from CHB donorb
|
|||
|---|---|---|---|---|---|
| HLA-DR13* positive
|
HLA-DR13* negative
|
||||
| Wk 1 | Wk 2 | Wk 1 | Wk 2 | ||
| Group 1 | 3 | 132.3 ± 37.3 | 1,870.8 ± 21.9 | 466.3 ± 150.9 | 3,875.9 ± 1,821.8 |
| Group 2 | 3 | 186.8 ± 74.6 | 1,250.5 ± 450.9 | 647.9 ± 134.3 | 3,325.7c |
| Group 3 | 3 | 318.6 ± 81.9 | 2,762.1 ± 492.0 | 874.3 ± 341.6 | 6,553.5 ± 152.6 |
| Group 4 | 3 | 244.7 ± 72.1 | 2,112.5c | 1,077.1 ± 129.8 | Not available |
a
See footnote a to Table 1.
b
Differences between combined groups 1 and 2 and combined groups 3 and 4 were statistically significant (P < 0.01) in both the DR13-positive and DR13-negative subject.
c
Only one sample is available.