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. 2024 Sep 14;16(9):e69421. doi: 10.7759/cureus.69421

Table 4. ABLLS change in difference scores between the control (ABA) and experimental (ABA + HBOT) groups.

Cohen's d: Small effect size = 0.20; Medium effect size = 0.50; Large effect size = 0.80 or higher

ABLLS: Assessment of Basic Language and Learning Skills; ABA: Applied Behavior Analysis; HBOT: Hyperbaric Oxygen Therapy

Scale Time HBOT mean (SD), n = 24 Non-HBOT mean (SD), n = 13 Mean difference 95% CI SE Effect size (Cohen's d) 95% CI for (Cohen's d) p-value
Receptive language Pretest 76.56 (37.26) 88.71 (56.12)  
Posttest 134.78 (47.22) 134.29 (63.15)
Difference 58.22 (43.18) 45.57 (33.23) 12.65 -17.00, 42.20 14.47 -0.348 -1.13, 0.441 0.3895 
Requests  Pretest 52.22 (24.67) 36..00 (27.47)  
Posttest 96.22 (36.75) 61.00 (34.39)
Difference 44.00 (31.13) 25.00 (21.38) 19.22 -1.05, 39.05 9.79 -0.773 -1.57, 0.039 0.0623 
Labeling Pretest 52.89 (43.49) 49.33 (48.82)  
Posttest 99.56 (55.07) 86.48 (61.90)
Difference 46.67 (43.83) 37.14 (31.46) 9.52 -19.40, 38.44 14.12 -0.269 -1.05, 0.518 0.5055 
Intraverbal Pretest 42.44 (35.21) 33.48 (36.07)  
Posttest 93.00 (55.10) 67.48 (55.04)
Difference 50.56 (40.47) 34.00 (36.71) 15.56 -14.31, 47.42 15.07 0.438 -1.22, 0.355 0.2813 
Spontaneous vocalizations Pretest 23.89 (12.13) 20.71 (13.07)  
Posttest 30.11 (8.19) 28.00 (10.19)
Difference 6.22 (11.68) 7.29 (8.21) -1.06 8.68, 6.55 3.72 -0.114 -0.668, 0.894 0.7769
Syntax and grammar Pretest 18.44 (15.83) 12.90 (21.39)  
Posttest 37.78 (28.87) 24.67 (25.22)
Difference 19.33 (16.39) 11.76 (17.92) 7.57 -6.71, 21.85 6.97 -0.433 -1.22, 0.360 0.2867
Social interactions Pretest 41.22 (26.07) 28.05 (20.33)  
Posttest 76.33 (40.86) 50.33 (27.71)
Difference 35.11 (25.97) 21.00 (22.29) 12.83 -4.24, 29.89 8.33 -0.613 -1.41, 0.189 0.1349
Generalized responding Pretest 7.78 (7.10) 9.76 (8.61)  
Posttest 16.56 (9.50) 17.52 (7.90)
Difference 8.78 (7.45) 7.76 (6.04) 1.02 -4.27, 6.30 2.58 -0.157 -0.937, 0.626 0.6966
Total score of assessment of language and basic living skills Pretest 315.44 (154.65) 278.95 (197.74)  
Posttest 584.33 (238.25) 469.76 (256.28)
Difference 268.89 (182.05) 190.81 (135.26) 78.08 -44.43, 200.59 59.81 -0.487 -1.14, 0.369 0.2024