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Aβ1-42 forms fibrillar aggregates in C. elegans neurons. (A, B) Fibril Aβ levels (A) and total Aβ levels (B) in worms were measured using a dot blot assay on the first or sixth day of adulthood. Total Aβ levels remained constant from day 1 to day 6, but fibril Aβ levels increased significantly. Aβ densitometry was quantified on the right. Data are presented as mean ± s.e.m. P values are derived from unpaired t-test. ****P < 0.0001; n.s., not significant.
