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Efalizumab cross-species translation between rabbit, monkey, and human. Two mechanisms that highly influence the PK of large IgG molecules are FcRn-binding and target-binding. Efalizumab binds to rabbit, non-human primate (NHP) and human FcRn. Target-binding to CD11a is only present in NHP and human, but not in rabbit (Bauer et al., 1999; Mortensen et al., 2005; Mould and Green, 2010). Created with BioRender.com.
