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. 2024 Oct 1;15:1418870. doi: 10.3389/fphar.2024.1418870

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Copyright © 2024 Franz, Jairam, Kuepfer and Hanke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Local sensitivity analysis of the rabbit, NHP and human models. Sensitivity of the model to single parameters, ranked by their impact on the predicted value of AUC extrapolated to infinity. CD11a (ref): CD11a reference concentration, K_D: equilibrium dissociation rate constant of the drug-target-complex, K_D,FcRn: equilibrium dissociation rate constant of the drug-FcRn-complex, k_int,C: internalization rate of the drug-target-complex, k_int,T: internalization rate of the target, k_off: dissociation rate constant of the drug-target-complex, NHP: non-human primate.