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. 2024 Oct 1;5:1460360. doi: 10.3389/fragi.2024.1460360

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Copyright © 2024 Shokhirev, Kramer, Corley, Cox, Cuellar and Johnson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Visual summary of the experimental approach. After demonstrating that the buccal clock CheekAge can be applied to Infinium HumanMethylation450 blood methylation data, we analyzed the relationship between mortality risk and the disparity between CheekAge and chronological age in the longitudinal Lothian Birth Cohorts. After identifying a significant relationship, we iteratively removed each CpG from the model and re-calculated the significance of the mortality association to better understand the relationship between each input and mortality.