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. 2024 Oct 1;5:1460360. doi: 10.3389/fragi.2024.1460360

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Copyright © 2024 Shokhirev, Kramer, Corley, Cox, Cuellar and Johnson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Performance of other published epigenetic age clocks in the Lothian Birth Cohorts. (A–F) Scatterplots showing predicted age versus chronological age and best fit linear regression lines for the Hannum 2013 (A), Horvath 2013 (B), Horvath 2018 (C), DNAm PhenoAge 2018 (D), Zhang 2019 (E), and CheekAge 2024 (F) clocks. Root mean squared error (RMSE), mean absolute error (MAE), and squared Pearson correlation coefficient (R²) values are shown for each clock. (G) Hazard ratios with 95% CI and FDR values are shown for each clock. Cox regression models include delta age, chronological age, timepoint, cohort, sex, and cell type composition as covariates.