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. 2024 May 29;37(6):1643–1652. doi: 10.1007/s40620-024-01973-0

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© The Author(s) 2024

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Fig. 2 — The influence of donor polygenic risk score on recipient graft survival. A Cox proportional hazards models for recipient graft survival (one model for each PRS: hypertension, IA, and stroke). Donor sex, donor age, recipient sex, recipient age, whether it was the recipient’s first transplant, year of transplant, and first 4 principal components of genetic ancestry are taken as covariates in each model. An individual who received a donor kidney in the top decile of polygenic risk for hypertension is 44% more likely to develop graft failure than those in the bottom decile of polygenic risk (95% CI 7%–93%). B Kaplan–Meier plot for graft survival split by donor hypertension polygenic risk (high vs low). p-value for differences in survival = 0.05. Finnish Red Cross Blood Service (FRCBS), kidney transplantation-genomic investigation of essential clinical concerns (KiT-GENIE), transplant lines (TL), United Kingdom and Ireland Renal Transplant consortium (UKIRTC)