Fig. 3.

The influence of donor polygenic risk score on recipient eGFR at 1-year post-transplant. A Linear models for recipient eGFR at 1-year post-transplant (one model for each PRS: hypertension, IA, and stroke). Donor sex, donor age, recipient sex, recipient age, whether it was the recipient’s first transplant, year of transplant, and first 4 principal components of genetic ancestry are included as covariates in each model. A standard deviation increase in donor IA and hypertension polygenic risk score results in 0.7 and 1.24 mL/min/1.73 m² decrease in recipient eGFR at 1-year post-transplant, respectively. eGFR was calculated using creatinine-based CKD-EPI equation. B Donor polygenic risk was split into low (bottom 10% of risk), intermediate (middle 80%) and high (top 10%). p-values are adjusted for multiple testing using a Bonferroni correction. Donor kidneys with low polygenic burden for hypertension and IA result in an approximately 5 mL/min/1.73 m² higher eGFR at 1 year post-transplant