Table 2.
Clinical characteristics before and after two intrauterine interventions in two FNAIT patients with the c.-132 C-c.329_330delAC haplotype.
| Case | CD36 gene (Mother) | Antibodies (Mother) |
Antibodies (Fetus) |
GA (weeks + day) |
FBS | Intra-uterine transfusion | Before Intra-uterine transfusion | After Intra-uterine transfusion | ||
|---|---|---|---|---|---|---|---|---|---|---|
| RBC(ml) | Hb(g L-1) | Hct(%) | Hb(g L-1) | Hct(%) | ||||||
| FNAIT-1 |
Haplotype 1: c.-132 A > C- c.329_330delAC Haplotype 2: No mutations in coding region |
Anti-CD36 antibodies Anti-HLA(62GE) |
Anti-CD36 antibodies | 23 | √ | 50 | 29 | 9.3 | 142 | 45 |
| 24 | √ | 40 | 74 | 21.8 | 148 | 44 | ||||
| 27 + 6 | √ | 40 | 66 | 19.2 | 142 | 41 | ||||
| 32 + 4 | √ | 30 | 103 | 30 | - | - | ||||
| FNAIT-2 |
Haplotype 1: c.-132 A > C- c.329_330delAC Haplotype 2: No mutations in coding region |
Anti-CD36 antibodies | Anti-CD36 antibodies | 28 + 1 | √ | 40 | 32 | 9.0 | 134 | 43 |