Fig. 3.

Low to moderate ethanol exposure significantly reduces IL-1β and TNF-α levels in both brain regions compared to air-exposed presymptomatic APP/PS1 mice. (A-C) ELISA assay to detect IL-1β and TNF-α levels in the cortex and hippocampus of presymptomatic APP/PS1 mice. (A) Comparison of air and ethanol groups including male and female (B) Comparison of only male mice air and ethanol groups (C) Comparison of only female mice air and ethanol groups. Data represent mean ± SEM; n = 5 per group. *P < 0.05 comparing each group. Two-tailed Mann–Whitney test. See Table S1 for full statistical information.