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HRDsig is superior to BRCAalt alone for enrichment of favorable rwPFS and rwOS. A, rwPFS and (B) rwOS is shown by the cohort subgroup, defined by BRCAalt and/or HRDsig. Interaction P values reflect models containing the two adjacent groups. Full interaction models are available in Supplementary Fig. S8. C, HRDsig detects 21.2% patients who are BRCA-WT and might benefit from mPARPi. D, Bimodal distribution of HRDsig score and overlap with BRCAalt status. tx, therapy.
