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The mechanism of Ber-lipo inhibiting the activation of TLR4/MyD88/NF-κB signaling pathway to restrain proinflammatory state. In brief, Ber-lipo inhibited TLR4 (LPS receptor) expression, then reduced the recruitment of MyD88, and further suppressed the IκBα activation, thereby hijacking NF-κB p65 nuclear translocation to mitigate inflammatory response.
