Table 5. Factors associated with female patients' awareness of isotretinoin treatment.

P: Pearson X2 test; $: exact probability test; * p<0.05 (significant)

Factors		Awareness level				p-value
		Poor (239)		Good (120)
		No	%	No	%
Age in years	16-25	167	69.3%	74	30.7%	.076$
	26-35	52	59.8%	35	40.2%
	36-45	14	56.0%	11	44.0%
	46+	6	100.0%	0	0.0%
Educational level	Below secondary	6	85.7%	1	14.3%	.716$
	Secondary	54	64.3%	30	35.7%
	University	169	66.8%	84	33.2%
	Post-graduate	10	66.7%	5	33.3%
Marital status	Single	177	67.8%	84	32.2%	.637
	Married	53	62.4%	32	37.6%
	Divorced / widow	9	69.2%	4	30.8%
Number of treatment courses with isotretinoin	1 course	160	70.5%	67	29.5%	.009*
	2 courses	51	68.0%	24	32.0%
	> 2 courses	28	49.1%	29	50.9%
Duration of taking Isotretinoin (months)	2-4 months	84	66.1%	43	33.9%	.826
	5-7 months	102	68.0%	48	32.0%
	8-10 months	32	61.5%	20	38.5%
	11-12 months	21	70.0%	9	30.0%
Have you been informed about the necessity of a negative pregnancy test before starting treatment?	Yes	94	56.3%	73	43.7%	.001*
	No	145	75.5%	47	24.5%
Have you been informed about the necessity of negative pregnancy tests during the treatment?	Yes	88	58.7%	62	41.3%	.007*
	No	151	72.2%	58	27.8%
Have you been informed that a negative pregnancy test is necessary 5 weeks after stopping the treatment?	Yes	72	54.1%	61	45.9%	.001*
	No	167	73.9%	59	26.1%
Have you been informed about the significance of using dual contraception techniques before starting treatment?	Yes	65	51.2%	62	48.8%	.001*
	No	174	75.0%	58	25.0%
Have you been informed about the significance of using dual contraception techniques during the treatment?	Yes	60	50.0%	60	50.0%	.001*
	No	179	74.9%	60	25.1%
Have you been informed about the significance of using dual contraception techniques 4 weeks after stopping the treatment?	Yes	65	52.0%	60	48.0%	.001*
	No	174	74.4%	60	25.6%
Have you signed the patient's consent form before beginning the treatment?	Yes	140	61.7%	87	38.3%	.010*
	No	99	75.0%	33	25.0%