Table 4.

Result of Mixed Model for Repeated Measures Analysis

RSI	Estimate	95% CI	P-value
BID vs QD	–0.596	–2.087 to 0.902	0.438
8-week vs baseline	–5.039	–6.446 to –3.632	< 0.001
16-week vs baseline	–6.213	–7.746 to –4.684	< 0.001
RSI baseline	0.710	0.626 to 0.795	< 0.001

RFS	Estimate	95% CI	P-value
BID vs QD	1.167	0.423 to 1.910	0.003
8-week vs baseline	–3.032	–3.397 to –2.662	< 0.001
16-week vs baseline	–4.752	–5.147 to –4.355	< 0.001
RFS baseline	0.003	–0.039 to 0.045	0.900

RSI, Reflux Symptom Index; BID, twice daily; QD, once daily; RFS, Reflux Finding Score.

P < 0.05 was considered statistically significant.