Figure 1. The fisherman approach. No CAD up to very severe CAD are presented as small fish (green) up to the biggest ones (purple), respectively. The nets with holes of different sizes, from the biggest up to the smallest, that is, dipyridamole (Dip), dobutamine (Dob), exercise (Ex), Dip–Dob and Dip–Ex, are presented. The ‘size of the holes’ for each stress was determined at the optimal cut-off between sensitivity and specificity where coronary angiography was used as the gold standard for each particular test in the same set of patients (204 tests in random order in 158 patients, 23 pre-PCI and post-PCI). It may be appreciated that the cut-off for Ex was exactly 50% stenosis (as postulated in animal experiments); for Dip, Dob, Dip–Dob and Dip–Ex, the cut-offs were 58%, 52%, 39% and 31%, respectively. Therefore, if the interest is just to catch a big fish, Dip will be used. CAD, coronary artery disease; PCI, percutaneous coronary intervention.