Table 3.

Genetic clusters associated with secondary metabolite production on the Streptomyces LB8 strain genome.

Region		Nucleotide
	Type	From	To	Most similar known cluster	Similarity	Associated function
1	Redox-cofactor	50,214	73,001	–	–	–
2	NAPAA	480,324	514,744	Stenothricin	13%	Antibiotic
3	Thiopeptide, LAP, siderophore	1,569,742	1,605,016	–	–	–
4	Lassopeptide	1,807,832	1,830,430	Chaxapeptin	28%	Lassopeptides
5	Siderophore	2,000,875	2,011,432	-	-	-
6	Ectoine	2,108,211	2,118,615	Ectoine	100%	Osmotic stress reaction
7	RiPP-like	2,442,726	2,452,532	–	–	–
8	T3PKS	2,458,946	2,500,004	Herboxidiene	5%	Antibacterial, antitumor
9	Terpene	3,025,566	3,049,031	Carotenoid	63%	Antibiotic (pigment)
10	Butyrolactone	3,558,699	3,567,982	Chondrochloren	50%	Antibiotic (latam among others), antitumor, antifungal
11	T2PKS	3,343,401	3,413,785	Mayamycin	72%	Antibiotic (macrolides), antitumor
12	Butyrolactone	3,558,699	3,567,892	Neocarzinostatin	6%	Antitumor antibiotic
13	Betalactone, siderophore, lanthipeptide-class-i	3,659,619	3,713,166	Desferrioxamine	83%	Antifungal, siderophores
14	NRPS-like, butyrolactone	3,714,886	3,756,801	Lactonamycin	5%	Antibacterial
15	Lanthipeptide-class-I	4,176,064	4,201,341	–	–	–
16	PKS-like, T1PKS	4,322,763	4,370,474	Arsono-polyketide	75%	Polyketide
17	NRPS, NAPAA, terpene	4,773,300	4,816,581	Stenothricin	13%	Antibiotic (including lipopeptides)
18	T2PKS	4,960,865	5,033,380	Spore pigment	83%	Antibiotic, antitumor, antifungal
19	RiPP-like	5,835,922	5,884,571	–	–	–
20	Butyrolactone	5,472,550	5,483,563	Cyphomycin	6%	Antifungal, antiplasmodial
21	PKS-like	5,835,922	5,884,571	Sanglifehrin	6%	Antibiotic, antitumor, immunosuppression
22	Terpene	5,889,153	5,909,308	Albaflavenone	100%	Antibacterial
23	Terpene	5,925,036	5,951,725	Hopene	53%	Antimicrobial and Antitumor

Clusters unmatched with known clusters are denoted with “-.”