Table 2.
Laboratory Data Findings
| Variable | Total (n = 70) | HIV Negative With CM (n = 44) | HIV Positive With CM (n = 26) | P Value |
|---|---|---|---|---|
| Blood test | ||||
| WBC, 103/μL | 7.6 ± 3.5 | 8.6 ± 3.7 | 5.8 ± 2.3 | <.001 |
| Hemoglobin, g/dL | 11.6 ± 2.4 | 11.3 ± 2.4 | 12.1 ± 2.5 | .225 |
| Platelet, 103/μL | 208.1 ± 86.4 | 199.3 ± 88.7 | 223 ± 81.9 | .270 |
| GOT, U/L (n = 68) | 43.3 ± 101 | 45 ± 123.6 | 40.4 ± 41.2 | .859 |
| GPT, U/L | 39.7 ± 71.5 | 39.5 ± 84.7 | 40 ± 42.3 | .979 |
| Total bilirubin, mg/dL (n = 50) | 0.7 ± 0.5 | 0.8 ± 0.6 | 0.5 ± 0.3 | .009 |
| BUN, mg/dL (n = 56) | 22.6 ± 23.3 | 27.4 ± 28 | 15.1 ± 9.5 | .051 |
| Creatinine, mg/dL (n = 69) | 1.3 ± 1.7 | 1.5 ± 2.1 | 1 ± 0.4 | .139 |
| Sodium, mmol/L | 136.1 ± 5.4 | 134.9 ± 5.6 | 138 ± 4.5 | .014 |
| Potassium, mmol/L | 3.8 ± 0.9 | 3.9 ± 1.1 | 3.6 ± 0.5 | .228 |
| CRP, mg/dL | 2.8 ± 3.8 | 3.6 ± 4.7 | 1.8 ± 1.7 | .130 |
| Serum lactate, mmol/L (n = 28) | 2.0 ± 1.5 | 1.8 ± 1.2 | 2.4 ± 2.0 | .293 |
| Serum CrAg >1:512 (n = 66) | 35 (53) | 20 (47.6) | 15 (62.5) | .244 |
| Fungemia | 27 (38.6) | 13 (26.6) | 14 (53.9) | .044 |
| Lumbar puncture study | ||||
| Open pressure, mm H2O | 251.2 ± 115.4 | 252.4 ± 109.9 | 249.1 ± 126.3 | .916 |
| Open pressure >250 mm H2O | 24 (34.3) | 15 (34.1) | 9 (34.6) | .964 |
| CSF WBC, /μL | 98.1 ± 150.4 | 125.7 ± 173.5 | 51.5 ± 84 | .045 |
| CSF Neutrophil, % | 13.9 ± 26.8 | 21 ± 31.6 | 1.9 ± 4.2 | <.001 |
| CSF Lymphocyte, % | 56.3 ± 41.9 | 58.3 ± 39.1 | 52.9 ± 46.9 | .621 |
| CSF Monocyte, % | 6.9 ± 14.1 | 9.3 ± 16.9 | 2.8 ± 5.9 | .024 |
| CSF-serum glucose ratio, % | 32.5 ± 20 | 26.3 ± 17.4 | 43 ± 19.8 | <.001 |
| CSF Glucose, mg/dL | 47.2 ± 34.3 | 41.3 ± 33.4 | 57.1 ± 34 | .065 |
| CSF Total protein, mg/dL | 194.8 ± 284.5 | 245.6 ± 332.3 | 108.8 ± 145.5 | .021 |
| CSF Lactate, mmol/La | 4.6 ± 3.4 | 5.4 ± 3.9 | 3.3 ± 1.9 | .012 |
| CSF Positive India ink | 54 (77.1) | 35 (79.6) | 19 (73.1) | .533 |
| CSF CrAg >1:512 | 45 (68.2) | 30 (71.4) | 15 (62.5) | .454 |
| CSF Positive culture | 58 (82.9) | 37 (84.1) | 21 (80.8) | .722 |
Data are presented as mean ± SD or No. (%). Bold indicates P < .05.
Abbreviations: BUN, blood urea nitrogen; CM, cryptococcal meningitis; CrAg, cryptococcal antigen; CRP, C-reactive protein; CSF, cerebrospinal fluid; GOT, glutamic oxaloacetic transaminase; GPT, glutamic pyruvic transaminase; WBC, white blood cell.
aThe reference range for CSF lactate in this study was <2.8 mmol/L.