Table 3.
Study Outcomes by Group
| Variable | Total (n = 70) | HIV Negative With CM (n = 44) | HIV Positive With CM (n = 26) | P Value |
|---|---|---|---|---|
| Temporary ventricular shunting | 5 (7.1) | 4 (9.1) | 1 (3.9) | .644 |
| Ventricular peritoneal shunt | 11 (15.7) | 8 (18.2) | 3 (11.5) | .521 |
| Antifungal | ||||
| Induction >2 wk | 58 (82.9) | 36 (81.8) | 22 (84.6) | .764 |
| Consolidation >8 wk | 40 (57.1) | 19 (43.2) | 21 (80.8) | .002 |
| Total antifungal duration, d | 209.6 ± 252.9 | 136.9 ± 150.7 | 332.8 ± 335.2 | .007 |
| Length of hospital stay, d | 37.0 ± 24.6 | 40.6 ± 26.1 | 30.8 ± 20.7 | .081 |
| CSF culture sterile | ||||
| >2 wk (n = 58) | 13 (22.4) | 7 (18.9) | 6 (28.6) | .397 |
| Time, d (n = 58) | 21.5 ± 34.2 | 13.1 ± 8.5 | 27.1 ± 43.2 | .280 |
| Death | ||||
| Day 30 | 9 (12.9) | 7 (15.9) | 2 (7.7) | .468 |
| Day 60 | 15 (21.4) | 12 (27.3) | 3 (11.5) | .121 |
| Day 90 | 19 (27.1) | 15 (34.1) | 4 (15.4) | .129 |
| Neurologic sequelaea | 12 (23.5) | 9 (31) | 3 (13.6) | .147 |
Data are presented as mean ± SD or No. (%). Bold indicates P < .05.
Abbreviations: CM, cryptococcal meningitis; CSF, cerebrospinal fluid.
aNeurologic sequelae were defined as patients who survived 12 months after diagnosis with a modified Rankin scale score ≥2.