Figure 3.

Intratumoral VSV-NDV treatment modulates CD44/CD62L expression patterns on T cells in B16 melanoma lesions and tumor-draining lymph nodes (TDLN). Bilateral B16OVA lesions and TDLNs were isolated from female C57Bl/6 mice treated with rVSV-NDV or PBS on day 10 post-treatment and analyzed by flow cytometry. (A) CD44/CD62L expression on CD8⁺ T cells and CD122⁺CD44⁺CD62L⁺CD8⁺ T cells on day 10 in the tumor. (B) CD44⁺CD62L⁻CD4⁺, CD44⁺CD62L⁻CD8⁺, and OVA-specific CD44⁺CD62L⁺CD8⁺ T cells on day 10 in the TDLNs. N = 5–15; data points indicate values of individual replicates (and group means + SD are presented as bars); * indicates p ˂ 0.05, ** indicates p ˂ 0.01.